Endocrine Abstracts

Background Somatostatin has many putative biological effects in the kidney such as influencing renal blood flow and urine volume, tubular transport and cell regulation. It exerts these effects via five identified G-protein linked receptors. However, only somatostatin receptor proteins 1 and 2A have been described in human kidney so far. In this study, we examined the distribution of somatostatin receptors (SSTRs) in normal human adult kidney. Methods Formalin fixed paraffin em...

In normal physiology, glucocorticoid receptor (GR) activation regulates cell type-dependent genes whose products influence metabolism, inflammation, cell cycle and apoptosis/cell survival pathways. Synthetic GR agonists, or glucocorticoids (GCs), are often used to treat hematologic malignancies because of GR’s ability to induce proapoptotic gene expression, inhibit nuclear factor–κB, and induce cell cycle arrest. In contrast, recent examination of GR expression ...